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The mean change in clinical rating was 3.2 (95% confidence interval [CI]: 2.93.5) and 3.9 (95% CI: 3.54.3), respectively, and the proportion of patients reaching a clinically important difference was 40.6% and 54.7%, respectively, according to the 2 evaluators

Lancet 390(10103):16641675 Athauda D, Gulyani S, Kumar Karnati H et al (2019) Utility of neuronal-derived exosomes to examine molecular mechanisms that affect motor function in patients with Parkinson disease: a secondary analysis of the exenatide-PD trial

That can introduce variability such as: This is one of the biggest distinctions between clinical peptide therapy and what is available online

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